According to new international research, taking aspirin increases the risk of heart failure by 26%. Other factors that contribute to heart failure besides aspirin include smoking, obesity, high cholesterol, diabetes, high blood pressure, and heart disease. The findings of the study were published in the ‘ESC Heart Failure Journal.’
‘This is the first study to show that people who are at risk of heart failure may get it by taking aspirin,’ said study author Dr. Blerim Mujaz of the University of Freiburg in Germany. When compared to those who do not take aspirin, the risk of heart failure may be increased.’
While the findings have yet to be validated, Dr. Blerim stated that the goal of this study was to determine whether its relationship with heart failure in people with and without heart disease, as well as whether drug use is associated with new diagnoses of heart failure in people at risk.
The study included 30,827 people aged 40 and up who were at risk of heart failure and were enrolled in the HOMEPAGE study from Western Europe and the Americas. Candidates classified as ‘at-risk’ had at least one of the following issues: smoking, obesity, diabetes, high blood pressure, high cholesterol, or heart disease. Aspirin use was recorded at the time of participation in the study, and participants were classified as users or non-users. The participants were tracked for the first occurrence of fatal or non-fatal heart failure necessitating hospitalization.
The average age of the study participants was 67 years old, with 34% being female. At the outset, it was discovered that at least 7,698 participants (25%) were taking aspirin. During a 5.3-year follow-up period, 1,330 people developed heart failure. After controlling for gender, age, body mass index, smoking, alcohol use, blood pressure, heart rate, cholesterol, creatinine, high blood pressure, diabetes, cardiovascular disease, and renin in the heart, the researchers looked at aspirin use and the incidence of heart failure. The relationship between failure and success was examined.
Researchers repeated the analysis after matching aspirin users and non-users for heart failure risk factors. Aspirin was linked to a 26% increased risk of heart failure in this matched study. The analysis was repeated after excluding patients with a history of cardiovascular disease to further investigate the findings. Aspirin use was associated with a 27% increased risk of heart failure in 22,690 participants (74% of whom were free of heart disease).
According to Dr. Mujaz, this was the first large study to look at the link between aspirin use and heart failure in people who had and didn’t have heart disease. One in every four study participants was found to be taking aspirin. They came to the conclusion that a large-scale study is required to confirm this. Until then, he advises using aspirin with caution.