Benefits of high-fat diets during pregnancy will boost the brain of the fetus

We all must have seen our grannies suggesting high-fat diets to the pregnant women in the house. Well, scientists have found out the reason behind this.

A study has revealed that a high-fat diet during gestation guards the fetus against changes in the brain that may lead to Alzheimer’s disease later.

Alzheimer’s is-

Simply put, it’s a form of dementia which ultimately leads to memory loss and other cognitive abilities. The most common symptoms are memory loss, inability to learn new things, problem in writing, reading, calculating, restlessness, anger, depression, hallucination, and inability to combine muscle movements. And there is no cure.

Although the risk of this disease comes in old age, there is no harm in preventive care. Yes, at an old age this situation can be terrifying.

Research findings

Recently a study was published in the journal Molecular Psychiatry and we quote. “In humans, it has been known that individuals whose mothers develop Alzheimer’s disease after the age of 65 are at increased risk of also developing the disease around the same age.” said senior investigator Dr Domenico Pratico, MD, Scott Richards North Star Foundation Chair for Alzheimer’s Research.

Genetic factors transmitted by mothers to their offspring seem like an obvious explanation behind this phenomenon, but so far no genes have been identified that could explain the maternal transmission of Alzheimer’s disease.

To better understand the unique relationship between maternal Alzheimer’s disease and risk in her offspring, Dr Pratico and his colleagues looked at maternal fat intake specifically during the gestation period in mice engineered to develop Alzheimer’s disease.

Pregnant mice were fed a high-fat diet from the beginning until the end of gestation. The moment offspring were born, mothers were switched to a regular diet, which was maintained during the lactation period. Offspring of these mothers were always kept at the same regular or standard diet throughout their life.

At 11 months of age, offspring underwent behavioural tests to assess learning ability and memory. “Surprisingly, we’ve found that animals from mothers fed a high-fat diet during gestation had better learning and memory skills than their counterparts born to mothers fed a regular diet during gestation,” Dr Pratico said.

The observed improvements in memory and learning were associated with the maintenance of good synaptic integrity. In fact, offspring from mothers exposed to a high-fat diet had significant improvement of synapse function when compared with offspring from mothers on a regular diet. Synapses, the places where neurons come together to relay information, play a vital role in learning and memory formation.


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